Hi.
I can confirm that a decent exhaust manifold and the 52mm throttle makes quite a difference ( to the early VVC anyway.)
I have a Piper exhaust manifold on the VVC F I was using and the mid range improvement was immediate but you should bear in mind that the early VVC engines had a not very good exhaust manifold to begin with, yours has the better one so I don't know what overall improvement a 4 2 1 would make.
I then fitted the 52mm throttle body, mostly because the stupid plastic one was sticking, but the top end was a lot snappier afterwards although I can't say there was any actual increase in power, it just felt better.
I should point out that it also has a decent exhaust box and a Pipercross intake system.
If you were to go further and have the head flowed then these additions will have a bigger effect.
Geoff.