I have customers who are using newer versions of MAC OS (but only with Intel Macbooks).
The problem is that I cannot officially support it because my Macbook Pro is too old (it's an 8,3) so if you have a problem then I would struggle to replicate it.
You can download the software and try it before purchasing an interface. It won't communicate with a vehicle but you can at least see if the software installs and runs.
Also there is a thread here
https://www.the-t-bar.com/forum/pscan-uk-diagnostic-tool-forum/97915-mac-osx-compatibility